Gene expression signatures of morphologically normal breast tissue identify basal-like tumors
نویسندگان
چکیده
منابع مشابه
A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines
Cell lines derived from human tumors have historically served as the primary experimental model system for exploration of tumor cell biology and pharmacology. Cell line studies, however, must be interpreted in the context of artifacts introduced by selection and establishment of cell lines in vitro. This complication has led to difficulty in the extrapolation of biology observed in cell lines t...
متن کاملGlycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression.
Glycosylation is the stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process have been associated with malignant transformation. Simultaneous analysis of the expression of all glycan-related genes clearly gives the advantage of enabling a comprehensive view of the genetic background of the glycobiological changes in cancer cells...
متن کاملGene expression profiles of the fibroblasts from breast tumors and normal tissue compared with the tumor expression profiles.
OBJECTIVE The study was designed to examine whether the gene expression profiles of fibroblast cell lines, established from the tumor and the normal tissue from the same breast, exhibit any similarities with the profiles of the original tissues. METHODS Fibroblast cell lines were established from invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) of the breast and the adjacen...
متن کاملEvaluation of Nucleostemin Gene Expression as a New Molecular Marker in Breast Tumors
Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...
متن کاملLoss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer.
Retinoids and their receptors [retinoic acid receptors (RARs) and retinoid X receptors] play an important role in maintaining the balance between proliferation and apoptosis. Recently, Deng et al. [Science (Washington DC), 274: 2057-2059, 1996] reported a loss of heterozygosity on chromosome 3p24 in breast cancer specimens and the morphologically normal appearing adjacent tissue. The 3p24 locus...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2006
ISSN: 1465-542X
DOI: 10.1186/bcr1608